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desvenlafaxine will boost the amount or influence of codeine by impacting hepatic enzyme CYP2D6 metabolism. Use Caution/Check. Desvenlafaxine inhibits CYP2D6; with higher desvenlafaxine doses (ie, four hundred mg) lower the CYP2D6 substrate dose by as much as fifty%; no dosage adjustment necessary with desvenlafaxine doses 7 consecutive days quickl